![5,6,7,8-Tetrahydro-imidazo[1,2-a]pyrazine|CS-W019673](https://file.chemscene.com/productPIC/CS-W019673.gif)
Lot numbers can be found on the outside label of a product:
tert-Butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate
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CAS No. 345311-03-7
- Cat. No. CS-W003676
- Purity≥95%
- MDL No.MFCD09878590
*For research and further manufacturing use only, not for direct human use.
![tert-Butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate|CS-W003676](https://file.chemscene.com/productPIC/CS-W003676.gif)
Structure of 345311-03-7
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General Information
- CAS No. 345311-03-7
- Cat. No. CS-W003676
- Purity ≥95%
- MDL No. MFCD09878590
- Storage RT, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₇N₃O₂
- Molecular Weight 223.27
- Synonym(s) Imidazo[1,2-a]pyrazine-7(8H)-carboxylic acid, 5,6-dihydro-, 1,1-dimethylethyl ester
- SMILES O=C(N1CC2=NC=CN2CC1)OC(C)(C)C
Description
tert-Butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate is a bench-stable, moisture-tolerant heterocyclic building block featuring a fused imidazopyrazine core. This compound integrates seamlessly into medicinal chemistry campaigns, enabling rapid access to nitrogen-rich scaffolds via straightforward deprotection. The tert-butyl ester group facilitates handling and purification while supporting orthogonal functionalization in multi-step syntheses.
Application
tert-Butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate serves as a versatile scaffold for constructing imidazopyrazine-based heterocycles, commonly found in bioactive molecules. The dihydro form offers stability and functional group tolerance, enabling selective oxidation or further derivatization. Its tert-butyl ester facilitates straightforward deprotection under mild acidic conditions, supporting rapid access to the parent carboxylic acid for conjugation or salt formation. This compound functions effectively in multi-step synthesis workflows requiring bench-stable intermediates with predictable reactivity.
Synthesis
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Route1
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345311-02-6 - ~36%
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In-stock
345311-03-7
References
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Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John Patent: US2003/236250 A1, 2003 ; Location in patent: Page 40 ;
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References
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WO2010/125101 A1, ; Page/Page column 58-59 ; WO 2010/125101 A1
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Route3
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In-stock
76003-29-7 -
645-36-3
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In-stock
345311-03-7
References
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WO2009/158394 A1, ; Page/Page column 69; 71 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 47.36
- LogP 1.6338
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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