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CS-W001157 4
Total: USD 88.00

6-(Difluoromethyl)pyridin-3-amine

  • CAS No. 913090-41-2

  • Cat. No. CS-W007162
  • Purity≥97%
  • MDL No.MFCD18384489

*For research and further manufacturing use only, not for direct human use.

6-(Difluoromethyl)pyridin-3-amine|CS-W007162

Structure of 913090-41-2

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General Information

  • CAS No. 913090-41-2
  • Cat. No. CS-W007162
  • Purity ≥97%
  • MDL No. MFCD18384489
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆F₂N₂
  • Molecular Weight 144.12
  • Synonym(s) 6-difluoromethylpyridin-3-ylamine
  • SMILES NC1=CC=C(N=C1)C(F)F

Description

6-(Difluoromethyl)pyridin-3-amine integrates a difluoromethyl group at the 6-position of pyridin-3-amine, delivering enhanced metabolic stability and improved lipophilic character. This electron-deficient heterocycle serves as a pivotal building block in medicinal chemistry, particularly for targeting kinase pathways and optimizing pharmacokinetic profiles in drug discovery campaigns.

Application

6-(Difluoromethyl)pyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group into bioactive molecules. Its pyridine nitrogen and primary amine functionality offer orthogonal reactivity for coupling and functionalization. The difluoromethyl moiety enhances metabolic stability and modulates electronic properties, making it valuable for optimizing pharmacokinetic profiles in drug discovery campaigns.

Synthesis

  • Route1
    • tert-Butyl (6-(difluoromethyl)pyridin-3-yl)carbamate|CS-0873652
      913091-96-0
    • ~82%
    • In-stock
      6-(Difluoromethyl)pyridin-3-amine|CS-W007162
      913090-41-2

    References

    • DAIICHI PHARMACEUTICAL CO., LTD. Patent: WO2006/109729 A1, 2006 ; Location in patent: Page/Page column 170 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H314-H317-H318-H330-H341-H360-H372-H411
Precautionary Statements : P260-P273-P280-P284

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.6014
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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