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CS-W001157 4
Total: USD 88.00

(2S,4S)-4-Phenylpyrrolidine-2-carboxylic acid hydrochloride

  • CAS No. 90657-53-7

  • Cat. No. CS-W022754
  • Purity≥98%
  • MDL No.MFCD08061932

*For research and further manufacturing use only, not for direct human use.

(2S,4S)-4-Phenylpyrrolidine-2-carboxylic acid hydrochloride|CS-W022754

Structure of 90657-53-7

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General Information

  • CAS No. 90657-53-7
  • Cat. No. CS-W022754
  • Purity ≥98%
  • MDL No. MFCD08061932
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄ClNO₂
  • Molecular Weight 227.69
  • Synonym(s) trans-4-Phenyl-L-proline hydrochloride
  • SMILES O=C(O)[C@H]1NC[C@H](C2=CC=CC=C2)C1.[H]Cl

Description

This bench-stable, moisture-tolerant chiral building block features a defined (2S,4S) stereochemistry and a phenyl-substituted pyrrolidine core. The hydrochloride salt enhances solubility and handling, enabling efficient incorporation into peptide-like scaffolds and medicinal chemistry campaigns requiring precise stereocontrol.

Application

(2S,4S)-4-Phenylpyrrolidine-2-carboxylic acid hydrochloride serves as a stereochemically defined building block for the synthesis of bioactive heterocycles and peptidomimetics. The phenyl-substituted pyrrolidine core provides rigidity and enhanced metabolic stability, while the carboxylic acid functionality enables direct coupling or derivatization in standard amide bond formation protocols. Bench-stable and readily purified by recrystallization, it facilitates efficient access to complex scaffolds relevant to medicinal chemistry campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   1.6385
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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