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CS-W001157 4
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(2S,4R)-1-[(tert-Butoxy)carbonyl]-4-phenylpyrrolidine-2-carboxylic acid

  • CAS No. 336818-78-1

  • Cat. No. CS-0054186
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(2S,4R)-1-[(tert-Butoxy)carbonyl]-4-phenylpyrrolidine-2-carboxylic acid|CS-0054186

Structure of 336818-78-1

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Description

This chiral pyrrolidine derivative features a tert-butoxycarbonyl-protected amine and a phenyl-substituted C4 position, enabling direct incorporation into peptide synthesis. The stereochemistry at C2 and C4 ensures high diastereoselectivity in coupling reactions. Bench-stable and moisture-tolerant, it streamlines the assembly of complex peptidomimetics under standard conditions.

Application

(2S,4R)-1-[(tert-Butoxy)carbonyl]-4-phenylpyrrolidine-2-carboxylic acid serves as a stereochemically defined pyrrolidine building block for medicinal chemistry applications. The Boc-protected amine and carboxylic acid functionalities enable sequential coupling reactions, while the phenyl-substituted pyrrolidine core provides structural rigidity and favorable physicochemical properties. Bench-stable and compatible with standard peptide synthesis protocols, it facilitates efficient access to complex heterocyclic scaffolds and bioactive molecules.

General Information

  • CAS No. 336818-78-1
  • Cat. No. CS-0054186
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₁NO₄
  • Molecular Weight 291.34
  • Synonym(s) (2S,4R)-BOC-4-PHENYL-PYRROLIDINE-2-CARBOXYLIC ACID
  • SMILES O=C([C@H]1N(C(OC(C)(C)C)=O)C[C@@H](C2=CC=CC=C2)C1)O

Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.8642
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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