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CS-W001157 4
Total: USD 88.00

2-Chloropyrimidine-5-carboxylic acid

  • CAS No. 374068-01-6

  • Cat. No. CS-W019608
  • Purity≥96%
  • MDL No.MFCD06739036

*For research and further manufacturing use only, not for direct human use.

2-Chloropyrimidine-5-carboxylic acid|CS-W019608

Structure of 374068-01-6

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General Information

  • CAS No. 374068-01-6
  • Cat. No. CS-W019608
  • Purity ≥96%
  • MDL No. MFCD06739036
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₂O₂
  • Molecular Weight 158.54
  • Synonym(s) None
  • SMILES O=C(C1=CN=C(Cl)N=C1)O

Description

2-Chloropyrimidine-5-carboxylic acid features a chlorine-substituted pyrimidine core paired with a carboxylic acid group, enabling direct functionalization in heterocyclic synthesis. This electron-deficient scaffold integrates readily into pharmaceutical intermediates and bioactive molecule frameworks under standard conditions.

Application

2-Chloropyrimidine-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C5 position via nucleophilic substitution. Its carboxylic acid group facilitates amide coupling and esterification, while the chloro substituent offers reliable electrophilic reactivity under mild conditions. The scaffold exhibits excellent bench stability and compatibility with standard purification techniques, making it well-suited for modular synthesis of heterocyclic compounds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.8282
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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