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CS-W001157 4
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3-Chloro-5-fluorobenzaldehyde

  • CAS No. 90390-49-1

  • Cat. No. CS-B0666
  • Purity≥98%
  • MDL No.MFCD02261734

*For research and further manufacturing use only, not for direct human use.

3-Chloro-5-fluorobenzaldehyde|CS-B0666

Structure of 90390-49-1

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General Information

  • CAS No. 90390-49-1
  • Cat. No. CS-B0666
  • Purity ≥98%
  • MDL No. MFCD02261734
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClFO
  • Molecular Weight 158.56
  • Synonym(s) None
  • SMILES O=CC1=CC(F)=CC(Cl)=C1

Description

3-Chloro-5-fluorobenzaldehyde features a dual-heteroatom-substituted aromatic ring that imparts enhanced electron deficiency and directional reactivity. This bench-stable aldehyde integrates readily into cross-coupling and condensation reactions, serving as a key building block for pharmaceutical intermediates and functional materials.

Application

3-Chloro-5-fluorobenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted heterocycles and biaryl scaffolds. Its orthogonal halogen functionality facilitates palladium-catalyzed cross-coupling reactions, while the aldehyde group supports imine formation, reductive amination, and nucleophilic addition processes. Bench-stable and compatible with standard purification methods, it functions reliably in multi-step synthetic sequences requiring precise regiocontrol.

Synthesis

  • Route1

    References

    • Meindl; Von Angerer; Schonenberger; Ruckdeschel Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1111 - 1118
  • Route2
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    • In-stock
      3-Chloro-5-fluorobenzaldehyde|CS-B0666
      90390-49-1

    References

    • Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1111 - 1118
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1111 - 1118

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.2916
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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