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CS-W001157 4
Total: USD 88.00

(2-Aminopyridin-4-yl)boronic acid

  • CAS No. 903513-62-2

  • Cat. No. CS-W005555
  • Purity≥95%
  • MDL No.MFCD11520501

*For research and further manufacturing use only, not for direct human use.

(2-Aminopyridin-4-yl)boronic acid|CS-W005555

Structure of 903513-62-2

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General Information

  • CAS No. 903513-62-2
  • Cat. No. CS-W005555
  • Purity ≥95%
  • MDL No. MFCD11520501
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇BN₂O₂
  • Molecular Weight 137.93
  • Synonym(s) (2-AMINO-4-PYRIDYL)BORONIC ACID
  • SMILES OB(C1=CC(N)=NC=C1)O

Description

This boronate moiety integrates seamlessly into Suzuki-Miyaura cross-coupling reactions, delivering efficient access to functionalized heteroaryl scaffolds. The para-amino group enhances solubility and directs regioselective transformation, while the bench-stable boronic acid functionality enables reliable handling under standard conditions.

Application

(2-Aminopyridin-4-yl)boronic acid serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The pendant amine group offers orthogonal reactivity for further functionalization, while the boronic acid moiety provides excellent stability, ease of purification, and compatibility with standard Suzuki-Miyaura coupling conditions. Its robustness and predictable reactivity make it a reliable scaffold for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 7 p. 1879 - 1882

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   79.37
  • LogP   -1.6564
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   1

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