2-Amino-4-chloropyridine

Name: 2-Amino-4-chloropyridine
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CAS No. 19798-80-2
Cat. No. CS-W008962
Purity≥96%
MDL No.MFCD04113820

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 19798-80-2

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General Information

CAS No. 19798-80-2
Cat. No. CS-W008962
Purity ≥96%
MDL No. MFCD04113820
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅ClN₂
Molecular Weight 128.56
Synonym(s) None
SMILES NC1=NC=CC(Cl)=C1

Description

4-Chloro-pyridin-2-ylamine features a chlorine-substituted pyridine ring paired with a primary amine group, enabling direct incorporation into heterocyclic scaffolds. This electron-deficient arylamine serves as a key building block in medicinal chemistry and materials science, offering high reactivity in cross-coupling and condensation reactions under standard conditions.

Application

4-Chloro-pyridin-2-ylamine serves as a versatile building block in medicinal chemistry, enabling direct incorporation into heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its ortho-chlorine facilitates selective functionalization, while the primary amine offers straightforward derivatization for conjugate addition or amide formation. The compound exhibits good bench stability and is compatible with standard purification protocols, making it a reliable reagent for API intermediate synthesis.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P302+P352

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Computational Chemistry Data

TPSA 38.91
LogP 1.3172
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Building Blocks Functional Group Amine

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Amino-4-chloropyridine

CAS No. 19798-80-2

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