8-Amino-6-methoxyquinoline

Name: 8-Amino-6-methoxyquinoline
Brand: ChemScene
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CAS No. 90-52-8
Cat. No. CS-W022555
Purity≥96%
MDL No.MFCD00672902

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 90-52-8

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Description

8-Amino-6-methoxyquinoline delivers a strategically positioned amino group and methoxy substituent on the quinoline scaffold, enabling facile functionalization in synthetic transformations. This electron-rich framework supports conjugation in fluorescent probes and serves as a key intermediate in medicinal chemistry applications requiring polar, aromatic heterocycles with enhanced solubility and stability under standard conditions.

Application

8-Amino-6-methoxyquinoline serves as a versatile building block in medicinal chemistry, enabling direct incorporation into heterocyclic scaffolds via palladium-catalyzed cross-coupling and electrophilic substitution reactions. The amino group facilitates derivatization, while the methoxy substituent enhances solubility and modulates electronic properties. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for multi-step synthesis campaigns targeting kinase inhibitors and antimalarial agents.

General Information

CAS No. 90-52-8
Cat. No. CS-W022555
Purity ≥96%
MDL No. MFCD00672902
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₀N₂O
Molecular Weight 174.20
Synonym(s) 6-Methoxyquinolin-8-ylamine
SMILES COC1=CC(N)=C2N=CC=CC2=C1

Computational Chemistry Data

TPSA 48.14
LogP 1.8256
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

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8-Amino-6-methoxyquinoline

CAS No. 90-52-8

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