Lot numbers can be found on the outside label of a product:
2-Methylquinolin-8-amine
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CAS No. 18978-78-4
- Cat. No. CS-W002143
- Purity≥98%
- MDL No.MFCD00023998
*For research and further manufacturing use only, not for direct human use.
Structure of 18978-78-4
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General Information
- CAS No. 18978-78-4
- Cat. No. CS-W002143
- Purity ≥98%
- MDL No. MFCD00023998
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₀N₂
- Molecular Weight 158.20
- Synonym(s) 8-Aminoquinaldine
- SMILES Cc1ccc2c(n1)c(N)ccc2
Description
2-Methylquinolin-8-amine features a sterically accessible quinoline scaffold with a strategically positioned amino group at the 8-position, enabling direct incorporation into transition metal-catalyzed coupling reactions. The methyl substitution enhances electronic modulation and improves solubility in common organic solvents, facilitating use in synthetic workflows requiring stable, bench-ready heterocyclic building blocks.
Application
2-Methylquinolin-8-amine serves as a versatile building block in medicinal chemistry, enabling direct access to quinoline-based scaffolds prevalent in kinase inhibitors and antimalarial agents. Its ortho-amino functionality facilitates electrophilic substitution, metal-catalyzed coupling, and cyclization reactions under standard conditions. The methyl group enhances metabolic stability and modulates electronic properties, while the amine provides a handle for derivatization via acylation, alkylation, or reductive amination. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step synthesis and scale-up workflows.
Synthesis
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Route1
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In-stock
881-07-2 - ~98%
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In-stock
18978-78-4
References
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VIFOR (INTERNATIONAL) AG Patent: US2012/214803 A1, 2012 ; Location in patent: Page/Page column 126 ; US 20120214803 A1
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Route2
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In-stock
146651-75-4 -
109-92-2 - ~50%
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In-stock
18978-78-4
References
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De, Kavita; Legros, Julien; Crousse, Benoit; Chandrasekaran, Srinivasan; Bonnet-Delpon, Daniele Organic and Biomolecular Chemistry, 2011 , vol. 9, # 2 p. 347 - 350
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Route3
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In-stock
826-81-3 - ~95%
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In-stock
18978-78-4
References
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Belser, Peter; Bernhard, Stefan; Guerig, Urs Tetrahedron, 1996 , vol. 52, # 8 p. 2937 - 2944
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H318
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Precautionary Statements : P264-P270-P280-P330-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.91
- LogP 2.12542
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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