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CS-W001157 4
Total: USD 88.00

2,5-Dichloroisonicotinic acid

  • CAS No. 88912-26-9

  • Cat. No. CS-W002633
  • Purity≥95%
  • MDL No.MFCD00466640

*For research and further manufacturing use only, not for direct human use.

2,5-Dichloroisonicotinic acid|CS-W002633

Structure of 88912-26-9

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General Information

  • CAS No. 88912-26-9
  • Cat. No. CS-W002633
  • Purity ≥95%
  • MDL No. MFCD00466640
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃Cl₂NO₂
  • Molecular Weight 192.00
  • Synonym(s) 2,5-Dichloropyridine-4-carboxylic Acid; 2,5-Dichloroisonicotinic acid
  • SMILES ClC1=CN=C(Cl)C=C1C(O)=O

Description

Calmagite is widely used in analytical chemistry as an indicator in the titration of calcium or magnesium with ethylenediaminetetraacetic acid (EDTA). It is also useful in the determination of magnesium in biological materials.

Application

2,5-Dichloroisonicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds and bioactive molecules. Its ortho-dichloro substitution pattern provides predictable reactivity in coupling reactions and facilitates downstream functionalization. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for scalable applications in API development and process chemistry workflows.

Synthesis

  • Route1
    • In-stock
      2,5-Dichloropyridine|CS-W016342
      16110-09-1
    • null|null
      124-38-9
    • ~87%
    • In-stock
      2,5-Dichloroisonicotinic acid|CS-W002633
      88912-26-9

    References

    • ARDEA BIOSCIENCES INC. Patent: WO2009/89263 A2, 2009 ; Location in patent: Page/Page column 95 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.0866
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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