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CS-W001157 4
Total: USD 88.00

1-Methylcyclopropanamine hydrochloride

  • CAS No. 88887-87-0

  • Cat. No. CS-W003769
  • Purity≥96%
  • MDL No.MFCD11109576

*For research and further manufacturing use only, not for direct human use.

1-Methylcyclopropanamine hydrochloride|CS-W003769

Structure of 88887-87-0

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General Information

  • CAS No. 88887-87-0
  • Cat. No. CS-W003769
  • Purity ≥96%
  • MDL No. MFCD11109576
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₀ClN
  • Molecular Weight 107.58
  • Synonym(s) 1-Methylcyclopropylamine hydrochloride
  • SMILES CC1(N)CC1.Cl

Description

1-Methylcyclopropanamine hydrochloride delivers a sterically constrained, nitrogen-rich scaffold ideal for probing bioactive conformational effects. This bench-stable salt features enhanced solubility and predictable protonation behavior, enabling efficient incorporation into peptide mimetics and medicinal chemistry libraries under standard conditions.

Application

1-Methylcyclopropanamine hydrochloride serves as a valuable chiral building block in medicinal chemistry, offering a rigid cyclopropyl scaffold with enhanced metabolic stability. Its amine functionality facilitates straightforward derivatization, including reductive amination and acylation, while the hydrochloride salt ensures excellent bench stability and ease of handling. This compound functions effectively in the synthesis of bioactive molecules requiring constrained alkylated nitrogen heterocycles.

Synthesis

  • Route1

    References

    • MITSUBISHI TANABE PHARMA CORPORATION Patent: WO2008/4698 A2, 2008 ; Location in patent: Page/Page column 129 ;
  • Route2
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    • In-stock
      1-Methylcyclopropanamine hydrochloride|CS-W003769
      88887-87-0

    References

    • MERCK and CO., INC. Patent: WO2008/85316 A1, 2008 ; Location in patent: Page/Page column 120 ; WO 2008/085316 A1
  • Route3

    References

    • Kirmse, Wolfgang; Rode, Jutta; Rode, Klaus Chemische Berichte, 1986 , vol. 119, # 12 p. 3672 - 3693

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   0.9194
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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