4-Chloro-6,7-difluoro-2-methylquinazoline

Name: 4-Chloro-6,7-difluoro-2-methylquinazoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 887592-02-1
Cat. No. CS-0152747
Purity≥97%
MDL No.MFCD06657231

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4-Chloro-6,7-difluoro-2-methylquinazoline|CS-0152747

Structure of 887592-02-1

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General Information

CAS No. 887592-02-1
Cat. No. CS-0152747
Purity ≥97%
MDL No. MFCD06657231
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₅ClF₂N₂
Molecular Weight 214.60
Synonym(s) None
SMILES CC1=NC2=CC(=C(C=C2C(=N1)Cl)F)F

Description

4-Chloro-6,7-difluoro-2-methylquinazoline features a highly electron-deficient quinazoline core with strategic halogen and methyl substitutions. This scaffold enables direct integration into medicinal chemistry campaigns, particularly for kinase inhibitor development. The difluoro substitution enhances metabolic stability while the chloro group provides a reactive handle for palladium-catalyzed coupling. Bench-stable and moisture-tolerant, it simplifies handling in diverse synthetic workflows.

Application

4-Chloro-6,7-difluoro-2-methylquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient access to kinase inhibitor scaffolds. Its electron-deficient quinazoline core facilitates nucleophilic substitution reactions, particularly at the C4-chloro position, and exhibits excellent bench stability. The 6,7-difluoro substitution enhances metabolic stability and modulates electronic properties, while the 2-methyl group provides steric control during downstream functionalization. This compound functions effectively in standard coupling protocols and is well-suited for parallel synthesis campaigns targeting biologically active heterocycles.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P264-P270-P330

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Computational Chemistry Data

TPSA 25.78
LogP 2.86982
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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4-Chloro-6,7-difluoro-2-methylquinazoline

CAS No. 887592-02-1

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