Tetrahydrofuran-3-amine

Name: Tetrahydrofuran-3-amine
Brand: ChemScene
Availability: InStock
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CAS No. 88675-24-5
Cat. No. CS-W011353
Purity≥97%
MDL No.MFCD07778394

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 88675-24-5
Cat. No. CS-W011353
Purity ≥97%
MDL No. MFCD07778394
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₉NO
Molecular Weight 87.12
Synonym(s) 3-furanamine, tetrahydro-
SMILES NC1COCC1

Description

Tetrahydrofuran-3-amine features a primary amine group tethered to a saturated five-membered ring, enabling versatile coupling reactions and serving as a key building block in bioactive molecule synthesis. This bench-stable, moisture-tolerant reagent integrates readily into diverse synthetic pathways.

Application

Tetrahydrofuran-3-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of bioactive molecules through its pendant primary amine and constrained tetrahydrofuran ring. The molecule exhibits good bench stability, facilitates efficient derivatization via amidation or alkylation, and functions as a key scaffold in targeted compound libraries due to its favorable solubility and metabolic profile.

Synthesis

Route1
- 100390-87-2
- ~%
- In-stock
  
  88675-24-5
References
- US2003/232783 A1, ; Page 12 ; US 20030232783 A1
Route2
- 18487-74-6
- ~%
- In-stock
  
  88675-24-5
References
- Zhurnal Obshchei Khimii, , vol. 25, p. 563,564; engl. Ausg. S. 531

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS05,GHS07
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H226-H302-H315-H318
Precautionary Statements : P210-P233-P280

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Computational Chemistry Data

TPSA 35.25
LogP -0.266
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydrofuran compounds

Key Words

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Tetrahydrofuran-3-amine

CAS No. 88675-24-5

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