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CS-W001157 4
Total: USD 88.00

4-Fluoropicolinic acid

  • CAS No. 886371-78-4

  • Cat. No. CS-W022184
  • Purity≥97%
  • MDL No.MFCD07374895

*For research and further manufacturing use only, not for direct human use.

4-Fluoropicolinic acid|CS-W022184

Structure of 886371-78-4

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General Information

  • CAS No. 886371-78-4
  • Cat. No. CS-W022184
  • Purity ≥97%
  • MDL No. MFCD07374895
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO₂
  • Molecular Weight None
  • Synonym(s) 4-FLUORO-PYRIDINE-2-CARBOXYLIC ACID
  • SMILES O=C(O)C1=NC=CC(F)=C1

Description

4-Fluoropicolinic acid features a fluorinated pyridine ring that enhances metabolic stability and modulates electronic properties. This electron-deficient heterocycle integrates readily into bioactive scaffolds, serving as a key building block in medicinal chemistry for targeted kinase inhibitors and CNS drug candidates.

Application

4-Fluoropicolinic acid serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds via standard coupling and cyclization protocols. Its ortho-fluoro substitution enhances metabolic stability and modulates electronic properties, while the carboxylic acid group facilitates direct derivatization or incorporation into peptide-like structures. Bench-stable and readily purified, it functions effectively in both solution-phase synthesis and solid-phase workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   0.9189
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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