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CS-W001157 4
Total: USD 88.00

Cyclopropyl(2-hydroxyphenyl)methanone

  • CAS No. 128405-69-6

  • Cat. No. CS-0227075
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Cyclopropyl(2-hydroxyphenyl)methanone|CS-0227075

Structure of 128405-69-6

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General Information

  • CAS No. 128405-69-6
  • Cat. No. CS-0227075
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O₂
  • Molecular Weight 162.19
  • Synonym(s) 2-hydroxyphenylcyclopropyl ketone
  • SMILES O=C(C1CC1)C2=CC=CC=C2O

Description

Cyclopropyl(2-hydroxyphenyl)methanone features a cyclopropyl group attached to a benzoyl scaffold bearing a phenolic hydroxyl at the ortho position. This structural motif imparts enhanced rigidity and polarity, facilitating integration into bioactive scaffolds. The molecule exhibits favorable solubility profiles and stability under standard handling conditions, making it suitable for medicinal chemistry applications involving hydrogen bonding or metal coordination.

Application

Cyclopropyl(2-hydroxyphenyl)methanone serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a phenolic hydroxyl group adjacent to a ketone functionality. Its structure facilitates downstream transformations such as reductive amination, nucleophilic addition, and transition-metal-catalyzed coupling reactions. The cyclopropyl moiety provides enhanced metabolic stability and conformational rigidity, while the ortho-hydroxyketone system supports intramolecular coordination in metal complexes. Bench-stable and amenable to standard purification methods, it functions reliably in multi-step synthesis of bioactive scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.9849
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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