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CS-W001157 4
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4-(Chlorosulfonyl)benzamide

  • CAS No. 885526-86-3

  • Cat. No. CS-0199255
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Chlorosulfonyl)benzamide|CS-0199255

Structure of 885526-86-3

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General Information

  • CAS No. 885526-86-3
  • Cat. No. CS-0199255
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₃S
  • Molecular Weight 219.65
  • Synonym(s) 4-carbamoylbenzenesulfonyl chloride
  • SMILES C1=C(C=CC(=C1)S(=O)(=O)Cl)C(=O)N

Description

4-(Chlorosulfonyl)benzamide features a chlorosulfonyl group directly attached to a benzamide scaffold, enabling direct electrophilic functionalization at the aromatic ring. This reactive moiety facilitates efficient coupling reactions in synthetic workflows, particularly for constructing sulfonamide derivatives used in medicinal chemistry and materials science.

Application

4-(Chlorosulfonyl)benzamide serves as a versatile bifunctional building block for the synthesis of sulfonamide-containing pharmaceutical intermediates and functionalized heterocycles. The chlorosulfonyl group enables efficient nucleophilic substitution reactions, while the amide functionality provides stability and compatibility with standard synthetic protocols. Its bench-stable nature and predictable reactivity facilitate straightforward incorporation into complex molecular architectures, particularly in the development of kinase inhibitors and other bioactive scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P304+P340-P405-P501

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Computational Chemistry Data

  • TPSA   77.23
  • LogP   0.713
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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