Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

(S)-1-((Benzyloxy)carbonyl)piperidine-3-carboxylic acid

  • CAS No. 88466-74-4

  • Cat. No. CS-0053786
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-1-((Benzyloxy)carbonyl)piperidine-3-carboxylic acid|CS-0053786

Structure of 88466-74-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 88466-74-4
  • Cat. No. CS-0053786
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₇NO₄
  • Molecular Weight 263.29
  • Synonym(s) 1,3-Piperidinedicarboxylic acid, 1-(phenylmethyl) ester, (3S)-
  • SMILES O=C([C@@H]1CN(C(OCC2=CC=CC=C2)=O)CCC1)O

Description

(S)-1-((Benzyloxy)carbonyl)piperidine-3-carboxylic acid features a chiral piperidine core with a benzyl-protected carboxylic acid at the 3-position, enabling selective functionalization in peptide synthesis. This configuration delivers enhanced stereocontrol during coupling reactions, while the benzyloxy carbonyl group provides stability under standard bench conditions and facilitates orthogonal deprotection via hydrogenolysis.

Application

(S)-1-((Benzyloxy)carbonyl)piperidine-3-carboxylic acid serves as a versatile chiral building block for the synthesis of bioactive heterocycles and peptide-like scaffolds. Its benzyl carbamate protection offers excellent bench stability and compatibility with standard coupling protocols, enabling efficient functionalization at the piperidine nitrogen. The carboxylic acid moiety facilitates direct amidation or esterification, supporting modular assembly of complex molecular architectures in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      501-53-1
    • In-stock
      Nipecotic acid|CS-W020556
      498-95-3
    • ~91%
    • In-stock
      (S)-1-((Benzyloxy)carbonyl)piperidine-3-carboxylic acid|CS-0053786
      88466-74-4

    References

    • SCHERING CORPORATION; PALANI, Anandan; BERLIN, Michael, Y.; ASLANIAN, Robert, G.; VACCARO, Henry, M.; CHAN, Tin-Yau; XIAO, Dong; DEGRADO, Sylvia; RAO, Ashwin, U.; CHEN, Xiao; LEE, Yoon, Joo; SOFOLARIDES, Michael, J.; SHAO, Ning; HUANG, Ying, R.; LIU, Zhidan; WANG, Li Yuan; PU, Haiyan Patent: WO2010/45303 A2, 2010 ; Location in patent: Page/Page column 101 ;
  • Route2
    • null|null
      868632-22-8
    • ~86%
    • In-stock
      (S)-1-((Benzyloxy)carbonyl)piperidine-3-carboxylic acid|CS-0053786
      88466-74-4

    References

    • Gessier, Francois; Schaeffer, Laurent; Kimmerlin, Thierry; Floegel, Oliver; Seebach, Dieter Helvetica Chimica Acta, 2005 , vol. 88, # 8 p. 2235 - 2249
  • Route3

    References

    • Helvetica Chimica Acta, , vol. 88, # 8 p. 2235 - 2249

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.1198
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 88466-74-4 sigma88466-74-4 manufacturer88466-74-4 price88466-74-4 structure88466-74-4 SDSbuy 88466-74-488466-74-4 supplier88466-74-4 uses88466-74-4 molecular weightprice of 88466-74-488466-74-4 chemical name formula of 88466-74-4
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label