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CS-W001157 4
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2-chloro-5-fluoropyridin-3-amine

  • CAS No. 884495-37-8

  • Cat. No. CS-0005591
  • Purity≥98%
  • MDL No.MFCD08277275

*For research and further manufacturing use only, not for direct human use.

2-chloro-5-fluoropyridin-3-amine|CS-0005591

Structure of 884495-37-8

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General Information

  • CAS No. 884495-37-8
  • Cat. No. CS-0005591
  • Purity ≥98%
  • MDL No. MFCD08277275
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄ClFN₂
  • Molecular Weight 146.55
  • Synonym(s) 3-PyridinaMine,2-chloro-5-fluoro-
  • SMILES NC1=CC(F)=CN=C1Cl

Description

2-Chloro-5-fluoropyridin-3-amine features a dual halogenated pyridine core with orthogonal reactivity, enabling selective coupling in late-stage functionalization. The electron-deficient ring and amine handle facilitate efficient incorporation into pharmaceutical scaffolds, particularly in kinase inhibitors and antiviral agents.

Application

2-Chloro-5-fluoropyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based heterocycles. Its orthogonal reactivity—where the amine group facilitates nucleophilic substitution while the chloro and fluoro substituents support palladium-catalyzed coupling—makes it ideal for modular synthesis of API candidates. Bench-stable and readily purified, it functions reliably in standard cross-coupling and cyclization workflows.

Synthesis

  • Route1
    • 2-Chloro-5-fluoronicotinamide|CS-0135776
      75302-64-6
    • ~%
    • In-stock
      2-chloro-5-fluoropyridin-3-amine|CS-0005591
      884495-37-8

    References

    • EP2022793 A1, ; Page/Page column 94 ; EP2022793 A1, ; Page/Page column 94 ; EP 2022793 A1
  • Route2

    References

    • US2013/225552 A1, ; Paragraph 0573 ;
  • Route3

    References

    • EP2394987 A1, ; Page/Page column 10 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.4563
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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