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CS-W001157 4
Total: USD 88.00

2,6-Dichloro-5-fluoropyridin-3-amine

  • CAS No. 152840-65-8

  • Cat. No. CS-0005626
  • Purity≥98%
  • MDL No.MFCD11044255

*For research and further manufacturing use only, not for direct human use.

2,6-Dichloro-5-fluoropyridin-3-amine|CS-0005626

Structure of 152840-65-8

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General Information

  • CAS No. 152840-65-8
  • Cat. No. CS-0005626
  • Purity ≥98%
  • MDL No. MFCD11044255
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂FN₂
  • Molecular Weight 181.00
  • Synonym(s) 3-Amino-2,6-dichloro-5-fluoropyridine
  • SMILES NC1=CC(F)=C(Cl)N=C1Cl

Description

Has Pharmaceutical applications. N-Benzylethanolamine is used in the synthesis of imidazoles as potent calcitonin (CGRP) antagonists. Also it aids in the preparation of benzofused hydroxamix acids, as useful fragments for the synthesis of histone deacetylase inhibitors.

Application

2,6-Dichloro-5-fluoropyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds via nucleophilic substitution and cross-coupling reactions. The ortho-dichloro pattern facilitates sequential functionalization, while the amino and fluoro groups provide complementary sites for derivatization. This compound exhibits good bench stability and compatibility with standard reaction conditions, making it well-suited for the synthesis of kinase inhibitors and other bioactive molecules.

Synthesis

  • Route1

    References

    • Helvetica Chimica Acta, , vol. 77, # 4 p. 1057 - 1064

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.1097
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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