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CS-W001157 4
Total: USD 88.00

4-Fluoro-2-nitropyridine

  • CAS No. 884495-09-4

  • Cat. No. CS-W007124
  • Purity≥97%
  • MDL No.MFCD08277259

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-2-nitropyridine|CS-W007124

Structure of 884495-09-4

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General Information

  • CAS No. 884495-09-4
  • Cat. No. CS-W007124
  • Purity ≥97%
  • MDL No. MFCD08277259
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃FN₂O₂
  • Molecular Weight 142.09
  • Synonym(s) None
  • SMILES O=[N+](C1=NC=CC(F)=C1)[O-]

Description

4-Fluoro-2-nitropyridine features a fluorine atom at the 4-position and a nitro group at the 2-position on a pyridine core, creating a highly electron-deficient heterocycle. This combination enables selective nucleophilic substitution reactions, particularly at the C4 position, while maintaining stability under standard bench conditions. The molecule serves as a key building block for pharmaceutical intermediates and functional materials requiring precise regiocontrol.

Application

4-Fluoro-2-nitropyridine serves as a versatile building block for heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its reactive C–F bond. The nitro group provides a handle for selective reduction and further functionalization, while the fluorine facilitates regioselective transformations. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.1289
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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