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CS-W001157 4
Total: USD 88.00

2,4-Dibromopyrimidine

  • CAS No. 3921-01-5

  • Cat. No. CS-W009107
  • Purity≥98%
  • MDL No.MFCD06798232

*For research and further manufacturing use only, not for direct human use.

2,4-Dibromopyrimidine|CS-W009107

Structure of 3921-01-5

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General Information

  • CAS No. 3921-01-5
  • Cat. No. CS-W009107
  • Purity ≥98%
  • MDL No. MFCD06798232
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂Br₂N₂
  • Molecular Weight None
  • Synonym(s) pyrimidine, 2,4-dibromo-
  • SMILES BrC1=NC(Br)=NC=C1

Description

2,4-Dibromopyrimidine serves as a pivotal building block in heterocyclic synthesis, featuring two bromine atoms at electron-rich positions that enable selective functionalization. This bench-stable reagent facilitates efficient coupling reactions under mild conditions, integrating readily into diverse molecular architectures.

Application

2,4-Dibromopyrimidine serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient C–H functionalization and cross-coupling reactions. Its dual bromine substituents facilitate sequential Pd-catalyzed transformations, offering precise control over substitution patterns. The molecule exhibits good bench stability and compatibility with standard reaction conditions, simplifying purification and scale-up. Functions effectively as a key intermediate in the construction of pyrimidine-based scaffolds found in pharmaceuticals and agrochemicals.

Synthesis

  • Route1

    References

    • Mosrin, Marc; Knochel, Paul Organic Letters, 2008 , vol. 10, # 12 p. 2497 - 2500
  • Route2
    • Uracil Fluorouracil Impurity|CS-0229732
      66-22-8
    • ~47%
    • In-stock
      2,4-Dibromopyrimidine|CS-W009107
      3921-01-5

    References

    • Decrane, Laurence; Pie, Nelly; Turck, Alain Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 4 p. 509 - 513
  • Route3
    • null|null
      3934-20-1
    • ~32%
    • In-stock
      2,4-Dibromopyrimidine|CS-W009107
      3921-01-5

    References

    • Schomaker; Delia Journal of Organic Chemistry, 2001 , vol. 66, # 21 p. 7125 - 7128

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.0016
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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