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CS-W001157 4
Total: USD 88.00

2,4-Dibromo-5-methylpyrimidine

  • CAS No. 494194-61-5

  • Cat. No. CS-0186499
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,4-Dibromo-5-methylpyrimidine|CS-0186499

Structure of 494194-61-5

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General Information

  • CAS No. 494194-61-5
  • Cat. No. CS-0186499
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄Br₂N₂
  • Molecular Weight 251.91
  • Synonym(s) Pyrimidine, 2,4-dibromo-5-methyl- (9CI)
  • SMILES CC1=CN=C(Br)N=C1Br

Description

2,4-Dibromo-5-methylpyrimidine features a sterically accessible pyrimidine core bearing two bromine substituents and a methyl group at the 5-position. This configuration enables direct functionalization in cross-coupling reactions, delivering substituted heterocycles with high regiocontrol. The compound exhibits bench-stable handling and compatibility with palladium-catalyzed transformations under standard conditions.

Application

2,4-Dibromo-5-methylpyrimidine serves as a versatile building block in heterocyclic synthesis, enabling efficient palladium-catalyzed cross-coupling reactions. Its bromine substituents at C2 and C4 positions offer high reactivity in Suzuki, Stille, and Negishi couplings, while the methyl group at C5 enhances stability and solubility. The compound exhibits excellent bench stability and facilitates rapid access to substituted pyrimidine scaffolds relevant to medicinal chemistry and agrochemical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.31002
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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