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CS-W001157 4
Total: USD 88.00

2-Chloro-5-fluoro-6-methylpyridine

  • CAS No. 884494-78-4

  • Cat. No. CS-W009124
  • Purity≥98%
  • MDL No.MFCD04972391

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-fluoro-6-methylpyridine|CS-W009124

Structure of 884494-78-4

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General Information

  • CAS No. 884494-78-4
  • Cat. No. CS-W009124
  • Purity ≥98%
  • MDL No. MFCD04972391
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClFN
  • Molecular Weight 145.56
  • Synonym(s) Pyridine,6-chloro-3-fluoro-2-methyl-
  • SMILES CC1=NC(Cl)=CC=C1F

Description

2-Chloro-5-fluoro-6-methylpyridine is a halogenated pyridine derivative featuring strategically positioned chloro and fluoro substituents alongside a methyl group. This combination imparts enhanced electron deficiency and steric profile, enabling efficient coupling in cross-coupling reactions. The compound exhibits bench-stable handling and compatibility with palladium-catalyzed transformations, making it a valuable building block for pharmaceutical intermediates and functional materials.

Application

2-Chloro-5-fluoro-6-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The chlorine and fluorine substituents facilitate selective functionalization, while the methyl group enhances metabolic stability. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for constructing heterocyclic scaffolds in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.18252
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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