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CS-W001157 4
Total: USD 88.00

6-Chloro-2-(difluoromethyl)-3-fluoropyridine

  • CAS No. 1805304-78-2

  • Cat. No. CS-0187200
  • Molecule weightNone
  • Purity≥98%
  • MDL No.MFCD25478439

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-(difluoromethyl)-3-fluoropyridine|CS-0187200

Structure of 1805304-78-2

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General Information

  • CAS No. 1805304-78-2
  • Cat. No. CS-0187200
  • Purity ≥98%
  • MDL No. MFCD25478439
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClF₃N
  • Molecular Weight None
  • Synonym(s) None
  • SMILES FC1=CC=C(Cl)N=C1C(F)F

Description

6-Chloro-2-(difluoromethyl)-3-fluoropyridine features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties. This fluorinated pyridine scaffold integrates readily into bioactive molecules, offering improved membrane permeability and resistance to oxidative degradation under standard conditions.

Application

6-Chloro-2-(difluoromethyl)-3-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated alkyl motifs into heterocyclic scaffolds. Its difluoromethyl group enhances metabolic stability and modulates lipophilicity, while the chloro and fluoro substituents provide orthogonal reactivity for palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The compound exhibits good bench stability and facilitates efficient synthesis of complex fluorinated pyridines used in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅲ
Hazard Statements : H225-H315-H319
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P362+P364-P370+P378-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.8117
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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