6-Chloro-3-fluoropicolinaldehyde

Name: 6-Chloro-3-fluoropicolinaldehyde
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CAS No. 884494-77-3
Cat. No. CS-W022481
Purity≥97%
MDL No.MFCD04972390

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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6-Chloro-3-fluoropicolinaldehyde|CS-W022481

Structure of 884494-77-3

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General Information

CAS No. 884494-77-3
Cat. No. CS-W022481
Purity ≥97%
MDL No. MFCD04972390
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClFNO
Molecular Weight 159.55
Synonym(s) 6-chloro-3-fluoro-pyridine-2-carbaldehyde
SMILES O=CC1=NC(Cl)=CC=C1F

Description

6-Chloro-3-fluoropicolinaldehyde features a strategically positioned chloro and fluoro substituent on the picolinaldehyde scaffold, delivering enhanced electrophilicity and directional control in C–C coupling reactions. This electron-deficient aldehyde integrates efficiently into heterocyclic architectures under mild conditions, offering high functional group tolerance and improved reaction selectivity in medicinal chemistry applications.

Application

6-Chloro-3-fluoropicolinaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-halogenated pyridine core facilitates palladium-catalyzed cross-coupling reactions and offers enhanced metabolic stability in drug candidates. The aldehyde functionality enables efficient imine formation, reductive amination, and incorporation into complex molecular architectures. Bench-stable and compatible with standard purification methods, it functions reliably in multi-step synthetic sequences requiring functional group tolerance and predictable reactivity.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 29.96
LogP 1.6866
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-3-fluoropicolinaldehyde

CAS No. 884494-77-3

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