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Ethyl 6-chloro-3-fluoropicolinate

  • CAS No. 1214363-79-7

  • Cat. No. CS-0160553
  • Molecule weight203.60
  • Purity≥98%
  • MDL No.MFCD14698362

*For research and further manufacturing use only, not for direct human use.

Ethyl 6-chloro-3-fluoropicolinate|CS-0160553

Structure of 1214363-79-7

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General Information

  • CAS No. 1214363-79-7
  • Cat. No. CS-0160553
  • Purity ≥98%
  • MDL No. MFCD14698362
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇ClFNO₂
  • Molecular Weight 203.60
  • Synonym(s) 2-Pyridinecarboxylic acid, 6-chloro-3-fluoro-, ethyl ester
  • SMILES O=C(OCC)C1=NC(Cl)=CC=C1F

Description

Ethyl 6-chloro-3-fluoropicolinate is a fluorinated pyridine derivative featuring complementary halogen substituents at the 6- and 3-positions. This electron-deficient heterocycle integrates readily into synthetic sequences requiring orthogonal reactivity, offering enhanced stability under standard conditions. The ester functionality enables direct manipulation or conversion to carboxylic acid analogs.

Application

Ethyl 6-chloro-3-fluoropicolinate serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles through palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The ortho-halogenation pattern facilitates selective functionalization, while the ester group supports downstream transformations. Bench-stable and readily purified, it functions effectively in standard synthetic workflows for API development and scaffold diversification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.0508
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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