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CS-W001157 4
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Methyl 2-bromo-6-methylisonicotinate

  • CAS No. 884494-71-7

  • Cat. No. CS-0041852
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 2-bromo-6-methylisonicotinate|CS-0041852

Structure of 884494-71-7

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General Information

  • CAS No. 884494-71-7
  • Cat. No. CS-0041852
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrNO₂
  • Molecular Weight 230.06
  • Synonym(s) 2-Bromo-6-methylisonicotinic acid methyl ester
  • SMILES O=C(OC)C1=CC(C)=NC(Br)=C1

Description

Methyl 2-bromo-6-methylisonicotinate is a halogenated pyridine derivative featuring a methyl ester and a bromine substituent at the 2- and 6-positions, respectively. This configuration imparts enhanced reactivity in cross-coupling transformations, enabling efficient C–C bond formation under palladium catalysis. The compound serves as a key intermediate in synthesizing bioactive heterocycles and functionalized aromatic systems.

Application

Methyl 2-bromo-6-methylisonicotinate serves as a versatile building block for the synthesis of substituted pyridine derivatives. The bromo group enables palladium-catalyzed cross-coupling reactions, while the ester functionality supports selective transformations under mild conditions. Its bench-stable nature and compatibility with common protecting groups facilitate efficient access to bioactive heterocycles and pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.93912
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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