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Structure of 883554-93-6
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Methyl 5-bromo-2-nitrobenzoate features a bromine substituent at the meta position relative to the ester group and a nitro group at the ortho position, creating a highly electron-deficient aromatic ring. This combination enables selective cross-coupling reactions under palladium catalysis, while the methyl ester serves as a stable handle for downstream functionalization. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols in medicinal chemistry and materials science applications.
Methyl 5-bromo-2-nitrobenzoate serves as a versatile building block for C–H functionalization and cross-coupling reactions, enabling efficient access to substituted aromatic scaffolds. The ortho-nitro and bromo groups provide complementary reactivity for sequential transformations, including Suzuki-Miyaura coupling and nitro reduction, with excellent chemoselectivity. Bench-stable and readily purified by flash chromatography, it facilitates streamlined synthesis of complex heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1325
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Class : 4.1
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Packing Group : Ⅲ
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Hazard Statements : H225-H261-H302+H312+H332-H315-H319
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Precautionary Statements : P210-P223-P231+P232-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P402+P404-P501
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Lot numbers can be found on the outside label of a product: