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CS-W001157 4
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5-(Piperidin-4-yl)-1,3,4-thiadiazol-2-amine

  • CAS No. 881040-24-0

  • Cat. No. CS-0315491
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Piperidin-4-yl)-1,3,4-thiadiazol-2-amine|CS-0315491

Structure of 881040-24-0

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General Information

  • CAS No. 881040-24-0
  • Cat. No. CS-0315491
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₂N₄S
  • Molecular Weight 184.26
  • Synonym(s) 5-(4-Piperidinyl)-1,3,4-thiadiazol-2-amine
  • SMILES NC1=NN=C(C2CCNCC2)S1

Description

5-(Piperidin-4-yl)-1,3,4-thiadiazol-2-amine features a rigid thiadiazole core fused with a piperidine ring, delivering enhanced solubility and metabolic stability. This scaffold integrates a primary amine at the 2-position, enabling facile conjugation in medicinal chemistry applications. The molecule exhibits favorable hydrogen-bonding capacity and electron-rich character, supporting strong target engagement in kinase inhibitor design and chemical biology probes.

Application

5-(Piperidin-4-yl)-1,3,4-thiadiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its piperidine moiety enhances solubility and pharmacokinetic properties, while the 1,3,4-thiadiazole core provides structural rigidity and hydrogen-bonding capability. The amine functionality facilitates straightforward derivatization via alkylation, acylation, or coupling reactions, supporting rapid library synthesis. This compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for high-throughput screening and lead optimization workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.83
  • LogP   0.5873
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   1

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