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Structure of 1359658-44-8
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tert-Butyl (2R)-2-cyanopiperazine-1-carboxylate is a stereochemically defined, bench-stable building block featuring a chiral piperazine core with a nitrile-bearing side chain. This configuration enables selective incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting CNS therapeutics and kinase inhibitors. The tert-butyloxycarbonyl group provides orthogonal protection, facilitating sequential functionalization under mild conditions.
tert-Butyl (2R)-2-cyanopiperazine-1-carboxylate serves as a stereochemically defined building block for the synthesis of piperazine-based pharmaceuticals and agrochemicals. The nitrile group enables selective transformations such as hydrolysis to carboxamides or reductive conversion to primary amines, while the tert-butyl ester provides bench stability and facile deprotection under mild acidic conditions. Its orthogonal functionality and configurational purity facilitate efficient access to complex heterocyclic scaffolds in medicinal chemistry workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: