(S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid

Name: (S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid
Brand: ChemScene
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CAS No. 848482-93-9
Cat. No. CS-0001877
Purity≥97%
MDL No.MFCD02179098

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid|CS-0001877

Structure of 848482-93-9

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General Information

CAS No. 848482-93-9
Cat. No. CS-0001877
Purity ≥97%
MDL No. MFCD02179098
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈N₂O₄
Molecular Weight 230.26
Synonym(s) (S)-4-N-Boc-piperazine-2-carboxylic acid
SMILES O=C(OC(C)(C)C)N1C[C@H](NCC1)C(O)=O

Description

This bench-stable, moisture-tolerant piperazine derivative features a protected amine and carboxylic acid functionality, enabling straightforward incorporation into peptide and macrocyclic scaffolds. The tert-butoxycarbonyl group facilitates selective deprotection under mild acidic conditions, while the electron-rich piperazine core supports efficient conjugation chemistry in synthetic medicinal chemistry workflows.

Application

(S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid serves as a versatile chiral building block for the synthesis of piperazine-based pharmaceutical intermediates. The Boc-protected amine and carboxylic acid functionalities enable orthogonal derivatization, facilitating peptide coupling, reductive amination, and cyclization reactions. Its bench-stable nature and compatibility with standard purification methods support efficient scale-up in medicinal chemistry campaigns.

Synthesis

Route1
- 1192014-44-0
- 147650-70-2
- ~%
- In-stock
  
  848482-93-9
References
- Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 18 p. 5440 - 5443

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 78.87
LogP 0.2799
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

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(S)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid

CAS No. 848482-93-9

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