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CS-W001157 4
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Piperazine-2-carboxylic acid

  • CAS No. 2762-32-5

  • Cat. No. CS-W002409
  • Purity≥97%
  • MDL No.MFCD00132878

*For research and further manufacturing use only, not for direct human use.

Piperazine-2-carboxylic acid|CS-W002409

Structure of 2762-32-5

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General Information

  • CAS No. 2762-32-5
  • Cat. No. CS-W002409
  • Purity ≥97%
  • MDL No. MFCD00132878
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀N₂O₂
  • Molecular Weight 130.15
  • Synonym(s) Piperazine-2-formic acid
  • SMILES OC(=O)C1CNCCN1

Description

Piperazine-2-carboxylic acid delivers a rigid, electron-rich scaffold ideal for medicinal chemistry applications. This bifunctional heterocycle integrates seamlessly into bioactive molecules, combining a polar carboxylate with a basic piperazine nitrogen to enhance solubility and target engagement.

Application

Piperazine-2-carboxylic acid serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amide coupling and functionalization protocols. Its carboxylic acid group facilitates direct conjugation or derivatization under common peptide synthesis conditions, while the piperazine core offers favorable solubility and metabolic stability. Bench-stable and readily purified by recrystallization, it functions as a key building block for targeted library synthesis and API development.

Synthesis

  • Route1
    • Pyrazine-2-carboxylic acid Bortezomib Impurity|CS-0169692
      98-97-5
    • ~%
    • In-stock
      Piperazine-2-carboxylic acid|CS-W002409
      2762-32-5

    References

    • Warner-Lambert Patent: US6251919 B1, 2001 ; US 6251919 B1
  • Route2
    • null|null
      77873-75-7
    • ~40%
    • In-stock
      Piperazine-2-carboxylic acid|CS-W002409
      2762-32-5

    References

    • Asher, Vikram; Becu, Christian; Anteunis, Marc J. O.; Callens, Roland Tetrahedron Letters, 1981 , vol. 22, p. 141 - 144

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   61.36
  • LogP   -1.3676
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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