1,4-Dioxaspiro[4.5]Decan-2-one

Name: 1,4-Dioxaspiro[4.5]Decan-2-one
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 4423-79-4
Cat. No. CS-0317774
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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1,4-Dioxaspiro[4.5]Decan-2-one|CS-0317774

Structure of 4423-79-4

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General Information

CAS No. 4423-79-4
Cat. No. CS-0317774
Purity ≥96%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₂O₃
Molecular Weight 156.18
Synonym(s) 1,4-Dioxaspiro[4.5]-2-decanone
SMILES C1CCC2(CC1)OCC(=O)O2

Description

1,4-Dioxaspiro[4.5]Decan-2-one features a rigid spirocyclic framework with dual ether linkages and a ketone at the bridgehead position. This configuration imparts high thermal stability and controlled polarity, enabling its use in complex molecular architectures where conformational rigidity and solubility balance are critical.

Application

1,4-Dioxaspiro[4.5]decane-2-one serves as a versatile bicyclic scaffold for medicinal chemistry and synthetic methodology development. Its rigid spirocyclic framework provides defined stereochemistry and spatial constraints beneficial in target-oriented synthesis. The ketone functionality enables standard transformations such as reduction, enolization, and nucleophilic addition, while the 1,4-dioxane moiety offers metabolic stability and favorable solubility. This compound functions effectively as a building block in heterocycle construction and is valued for its bench stability and compatibility with diverse reaction conditions.

Synthesis

Route1
- In-stock
  
  79-14-1
- 108-94-1
- ~73%
- In-stock
  
  4423-79-4
References
- Perez, Manuel; Perez, Daniel I.; Martinez, Ana; Castro, Ana; Gomez, Generosa; Fall, Yagamare Chemical Communications, 2009 , # 22 p. 3252 - 3254
Route2
- In-stock
  
  33581-77-0
- 108-94-1
- ~99%
- In-stock
  
  4423-79-4
References
- Pearson, William H.; Cheng, Minn-Chang Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1353 - 1355
Route3
- 933-40-4
- In-stock
  
  33581-77-0
- ~83%
- In-stock
  
  4423-79-4
References
- Pearson, William H.; Cheng, Minn-Chang Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1353 - 1355

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 35.53
LogP 1.2202
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Dioxolane compounds

Building Blocks Skeleton Fatty ring compounds Cyclohexane compounds

Key Words

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1,4-Dioxaspiro[4.5]Decan-2-one

CAS No. 4423-79-4

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