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CS-W001157 4
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1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

  • CAS No. 879132-46-4

  • Cat. No. CS-M0144
  • Purity≥97%
  • MDL No.MFCD17016028

*For research and further manufacturing use only, not for direct human use.

1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine|CS-M0144

Structure of 879132-46-4

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General Information

  • CAS No. 879132-46-4
  • Cat. No. CS-M0144
  • Purity ≥97%
  • MDL No. MFCD17016028
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₀N₂OSi
  • Molecular Weight 248.40
  • Synonym(s) 1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridine
  • SMILES C[Si](C)(C)CCOCN(C=C1)C2=C1C=CC=N2

Description

This pyrrolopyridine derivative features a silyl-protected alcohol moiety enabling stable storage and selective deprotection under mild conditions. The trimethylsilyl group enhances solubility and compatibility in synthetic workflows, while the fused heterocyclic core provides a rigid scaffold for C–H functionalization and transition-metal-catalyzed coupling reactions.

Application

1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine serves as a robust building block for heterocyclic synthesis, enabling efficient access to pyrrolopyridine-based scaffolds. The trimethylsilyl ether group provides excellent bench stability and facilitates orthogonal deprotection under mild conditions. It functions effectively in palladium-catalyzed coupling reactions and supports diverse functionalization strategies in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   27.05
  • LogP   3.3486
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   5

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