2-Chloro-5-hydrazinylpyridine

Name: 2-Chloro-5-hydrazinylpyridine
Brand: ChemScene
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CAS No. 145934-89-0
Cat. No. CS-0098110
Purity≥95%
MDL No.MFCD16251142

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-Chloro-5-hydrazinylpyridine|CS-0098110

Structure of 145934-89-0

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Description

2-Chloro-5-hydrazinylpyridine features a reactive hydrazino group positioned ortho to a chloropyridine moiety, enabling selective coupling reactions in heterocyclic synthesis. This bifunctional scaffold integrates readily into advanced intermediates for pharmaceuticals and agrochemicals. The compound exhibits enhanced stability under standard bench conditions and facilitates efficient derivatization through nucleophilic substitution or condensation pathways.

Application

2-Chloro-5-hydrazinylpyridine serves as a versatile building block in medicinal chemistry, enabling direct substitution at the pyridine ring to access functionalized heterocycles. Its hydrazinyl group facilitates coupling reactions and cyclization pathways, while the chloro substituent offers orthogonal reactivity for cross-coupling or nucleophilic displacement. The compound exhibits good bench stability and compatibility with standard purification techniques, making it well-suited for iterative synthesis of API-relevant scaffolds.

General Information

CAS No. 145934-89-0
Cat. No. CS-0098110
Purity ≥95%
MDL No. MFCD16251142
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₆ClN₃
Molecular Weight None
Synonym(s) Pyridine, 2-chloro-5-hydrazino- (9CI)
SMILES NNC1=CN=C(Cl)C=C1

Computational Chemistry Data

TPSA 50.94
LogP 1.0206
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-hydrazinylpyridine

CAS No. 145934-89-0

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