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CS-W001157 4
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(5-(Methoxycarbonyl)thiophen-2-yl)boronic acid

  • CAS No. 876189-21-8

  • Cat. No. CS-0176099
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(5-(Methoxycarbonyl)thiophen-2-yl)boronic acid|CS-0176099

Structure of 876189-21-8

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General Information

  • CAS No. 876189-21-8
  • Cat. No. CS-0176099
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BO₄S
  • Molecular Weight 185.99
  • Synonym(s) THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER-5-BORIC ACID
  • SMILES COC(C1=CC=C(S1)B(O)O)=O

Description

This boronate moiety integrates a methoxycarbonyl group at the 5-position of a thiophene ring, delivering enhanced solubility and stability under standard conditions. The electron-deficient thiophene core facilitates efficient cross-coupling reactions, enabling rapid access to functionalized heterocycles in synthetic workflows.

Application

(5-(Methoxycarbonyl)thiophen-2-yl)boronic acid serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The methoxycarbonyl group provides orthogonal functionality for downstream derivatization, while the boronic acid moiety offers excellent bench stability and compatibility with diverse reaction conditions. Its predictable reactivity and ease of purification make it well-suited for medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.76
  • LogP   -0.7855
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   2

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