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CS-W001157 4
Total: USD 88.00

(5-Formylthiophen-2-yl)boronic acid

  • CAS No. 4347-33-5

  • Cat. No. CS-W000931
  • Purity≥97%
  • MDL No.MFCD02093666

*For research and further manufacturing use only, not for direct human use.

(5-Formylthiophen-2-yl)boronic acid|CS-W000931

Structure of 4347-33-5

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General Information

  • CAS No. 4347-33-5
  • Cat. No. CS-W000931
  • Purity ≥97%
  • MDL No. MFCD02093666
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅BO₃S
  • Molecular Weight 155.97
  • Synonym(s) 5-Formylthiophene-2-boronic acid
  • SMILES O=Cc1ccc(s1)B(O)O

Description

This boronate moiety integrates a formyl group at the 5-position of thiophene, enabling direct functionalization in Suzuki-Miyaura couplings. The electron-deficient thiophene ring enhances reactivity while maintaining bench-stable handling under standard conditions.

Application

(5-Formylthiophen-2-yl)boronic acid serves as a versatile building block for Suzuki-Miyaura coupling reactions, enabling efficient construction of biologically relevant thiophene-based scaffolds. The formyl group provides orthogonal functionality for downstream derivatization via reductive amination or condensation reactions. Bench-stable and compatible with a range of functional groups, it facilitates streamlined synthesis of complex heterocycles and potential API intermediates in medicinal chemistry workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.7596
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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