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CS-W001157 4
Total: USD 88.00

2-Fluoro-6-methylpyridine-5-boronic acid

  • CAS No. 904326-91-6

  • Cat. No. CS-W003044
  • Purity≥97%
  • MDL No.MFCD03411561

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-6-methylpyridine-5-boronic acid|CS-W003044

Structure of 904326-91-6

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General Information

  • CAS No. 904326-91-6
  • Cat. No. CS-W003044
  • Purity ≥97%
  • MDL No. MFCD03411561
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BFNO₂
  • Molecular Weight 154.94
  • Synonym(s) boronic acid, B-(6-fluoro-2-methyl-3-pyridinyl)-
  • SMILES CC1=C(B(O)O)C=CC(F)=N1

Description

2-Fluoro-6-methylpyridine-5-boronic acid features a pyridine core with strategically positioned fluorine and methyl groups that enhance regioselectivity in cross-coupling reactions. The boronic acid moiety enables efficient Suzuki-Miyaura coupling under mild conditions, delivering functionalized heterocycles with high fidelity. This bench-stable reagent combines electronic tuning with predictable reactivity for streamlined synthesis.

Application

2-Fluoro-6-methylpyridine-5-boronic acid serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki-Miyaura reactions to construct biaryl and heteroaryl scaffolds. Its fluorinated pyridine core provides enhanced metabolic stability and tunable electronic properties, while the boronic acid functionality offers reliable coupling efficiency and bench-stable handling. The methyl group enables further functionalization, supporting the synthesis of complex pharmaceutical intermediates and agrochemical motifs.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.79108
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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