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CS-W001157 4
Total: USD 88.00

(2-Fluoro-6-methylpyridin-3-yl)boronic acid

  • CAS No. 906744-85-2

  • Cat. No. CS-0109931
  • Purity≥98%
  • MDL No.MFCD03411560

*For research and further manufacturing use only, not for direct human use.

(2-Fluoro-6-methylpyridin-3-yl)boronic acid|CS-0109931

Structure of 906744-85-2

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General Information

  • CAS No. 906744-85-2
  • Cat. No. CS-0109931
  • Purity ≥98%
  • MDL No. MFCD03411560
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BFNO₂
  • Molecular Weight 154.93
  • Synonym(s) 2-Fluoro-6-methylpyridine-3-boronic acid
  • SMILES CC1=CC=C(B(O)O)C(F)=N1

Description

This boronate moiety integrates a fluorinated pyridine scaffold, offering enhanced stability and selective reactivity in cross-coupling processes. The para-fluoro and ortho-methyl substituents modulate electronic properties and sterics, enabling efficient transformations under mild conditions.

Application

(2-Fluoro-6-methylpyridin-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The fluorine and methyl substituents provide orthogonal functionalization potential and enhance metabolic stability in pharmaceutical applications. Bench-stable and readily purified by flash chromatography or recrystallization, it functions reliably in standard coupling protocols with broad compatibility across diverse aryl halides.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.79108
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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