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CS-W001157 4
Total: USD 88.00

O-(4-Methoxybenzyl)hydroxylamine hydrochloride

  • CAS No. 876-33-5

  • Cat. No. CS-W005477
  • Purity≥97%
  • MDL No.MFCD01114582
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

O-(4-Methoxybenzyl)hydroxylamine hydrochloride|CS-W005477

Structure of 876-33-5

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Description

O-(4-Methoxybenzyl)hydroxylamine hydrochloride offers a stable, moisture-tolerant platform for selective N-arylation reactions. The electron-rich methoxy group enhances nucleophilicity, while the benzylic linker enables straightforward deprotection under mild acidic conditions. This reagent integrates efficiently into synthetic sequences requiring protected hydroxylamine functionality.

Application

O-(4-Methoxybenzyl)hydroxylamine hydrochloride serves as a stable, bench-ready precursor for the synthesis of oxime derivatives and nitrogen-containing heterocycles. Its protected hydroxylamine functionality enables selective C–N bond formation under mild conditions, with excellent functional group tolerance and straightforward purification via crystallization or acid-base extraction. Widely employed in medicinal chemistry campaigns for amine bioisostere replacement and scaffold diversification, it facilitates efficient access to pharmacologically relevant scaffolds through reliable reductive amination and cyclization protocols.

General Information

  • CAS No. 876-33-5
  • Cat. No. CS-W005477
  • Purity ≥97%
  • MDL No. MFCD01114582
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂ClNO₂
  • Molecular Weight 189.64
  • Synonym(s) O-(4-Methoxy--benzyl)hydroxylamine hydrochloride
  • SMILES NOCC1=CC=C(OC)C=C1.[H]Cl

Computational Chemistry Data

  • TPSA   44.48
  • LogP   1.5073
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group :
Hazard Statements : H228-H315-H319
Precautionary Statements : P210-P240-P264-P280-P370+P378

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