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CS-W001157 4
Total: USD 88.00

O-(4-Methoxybenzyl)hydroxylamine hydrochloride

  • CAS No. 876-33-5

  • Cat. No. CS-W005477
  • Molecule weight189.64
  • Purity≥97%
  • MDL No.MFCD01114582

*For research and further manufacturing use only, not for direct human use.

O-(4-Methoxybenzyl)hydroxylamine hydrochloride|CS-W005477

Structure of 876-33-5

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General Information

  • CAS No. 876-33-5
  • Cat. No. CS-W005477
  • Purity ≥97%
  • MDL No. MFCD01114582
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂ClNO₂
  • Molecular Weight 189.64
  • Synonym(s) O-(4-Methoxy--benzyl)hydroxylamine hydrochloride
  • SMILES NOCC1=CC=C(OC)C=C1.[H]Cl

Description

O-(4-Methoxybenzyl)hydroxylamine hydrochloride offers a stable, moisture-tolerant platform for selective N-arylation reactions. The electron-rich methoxy group enhances nucleophilicity, while the benzylic linker enables straightforward deprotection under mild acidic conditions. This reagent integrates efficiently into synthetic sequences requiring protected hydroxylamine functionality.

Application

O-(4-Methoxybenzyl)hydroxylamine hydrochloride serves as a stable, bench-ready precursor for the synthesis of oxime derivatives and nitrogen-containing heterocycles. Its protected hydroxylamine functionality enables selective C–N bond formation under mild conditions, with excellent functional group tolerance and straightforward purification via crystallization or acid-base extraction. Widely employed in medicinal chemistry campaigns for amine bioisostere replacement and scaffold diversification, it facilitates efficient access to pharmacologically relevant scaffolds through reliable reductive amination and cyclization protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅲ
Hazard Statements : H228-H315-H319
Precautionary Statements : P210-P240-P264-P280-P370+P378

Quality Control

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Computational Chemistry Data

  • TPSA   44.48
  • LogP   1.5073
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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