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1H-Pyrrolo[3,2-b]pyridine-5-carboxylic acid

  • CAS No. 872355-64-1

  • Cat. No. CS-0052492
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1H-Pyrrolo[3,2-b]pyridine-5-carboxylic acid|CS-0052492

Structure of 872355-64-1

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General Information

  • CAS No. 872355-64-1
  • Cat. No. CS-0052492
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O₂
  • Molecular Weight 162.15
  • Synonym(s) 4-AZAINDOLE-5-CARBOXYLIC ACID
  • SMILES OC(=O)C1=CC=C2NC=CC2=N1

Description

This pyrrolopyridine carboxylic acid features a fused heteroaromatic core with a pendant acidic functionality, enabling direct incorporation into bioactive scaffolds. The electron-deficient ring system supports efficient coupling reactions, while the carboxylic acid group facilitates derivatization under standard conditions.

Application

1H-Pyrrolo[3,2-b]pyridine-5-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its carboxylic acid functionality enables straightforward derivatization via amide coupling, esterification, or metal complexation, while the fused pyrrolopyridine core provides structural rigidity and enhanced π-conjugation. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for use in multi-step synthesis and API scaffold development.

Synthesis

  • Route1

    References

    • WO2006/112828 A1, ; Page/Page column 83 ; WO 2006/112828 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.2611
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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