1H-Pyrrolo[3,2-b]pyridine-5-carbonitrile

Name: 1H-Pyrrolo[3,2-b]pyridine-5-carbonitrile
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CAS No. 146767-63-7
Cat. No. CS-0044716
Purity≥98%
MDL No.MFCD09909831

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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1H-Pyrrolo[3,2-b]pyridine-5-carbonitrile|CS-0044716

Structure of 146767-63-7

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General Information

CAS No. 146767-63-7
Cat. No. CS-0044716
Purity ≥98%
MDL No. MFCD09909831
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅N₃
Molecular Weight 143.15
Synonym(s) 1H-Pyrrolo[3,2-b]pyridine-5-carbonitrile(9CI)
SMILES N#CC1=CC=C(NC=C2)C2=N1

Description

1H-Pyrrolo[3,2-b]pyridine-5-carbonitrile is a nitrogen-rich heterocycle featuring a fused pyrrole-pyridine core with a strategically positioned nitrile group. This scaffold delivers enhanced electronic density and planarity, enabling efficient integration into advanced pharmaceutical intermediates and functional materials. The nitrile moiety serves as a key handle for downstream derivatization, supporting rapid diversification in medicinal chemistry campaigns.

Application

1H-Pyrrolo[3,2-b]pyridine-5-carbonitrile serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to fused polycyclic scaffolds. The nitrile group provides a robust handle for downstream functionalization via hydrolysis, reduction, or nucleophilic addition, while the pyrrolopyridine core exhibits favorable stability and compatibility with standard coupling reactions. Its defined regiochemistry supports predictable reactivity in cross-coupling and transition-metal-catalyzed transformations, making it a reliable intermediate for drug discovery campaigns requiring complex nitrogen-rich frameworks.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 52.47
LogP 1.43458
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrrole compounds

Key Words

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1H-Pyrrolo[3,2-b]pyridine-5-carbonitrile

CAS No. 146767-63-7

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