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CS-W001157 4
Total: USD 88.00

(5-Fluoropyridin-3-yl)boronic acid

  • CAS No. 872041-86-6

  • Cat. No. CS-D0337
  • Purity≥95%
  • MDL No.MFCD07368243

*For research and further manufacturing use only, not for direct human use.

(5-Fluoropyridin-3-yl)boronic acid|CS-D0337

Structure of 872041-86-6

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General Information

  • CAS No. 872041-86-6
  • Cat. No. CS-D0337
  • Purity ≥95%
  • MDL No. MFCD07368243
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅BFNO₂
  • Molecular Weight 140.91
  • Synonym(s) boronic acid, B-(5-fluoro-3-pyridinyl)-
  • SMILES OB(C1=CC(F)=CN=C1)O

Description

L-tert-Leucine is an essential amino acid and makes up one third of our muscle protein. It can be used as a food additive. It is used in the formation of sterols. It is used in the production of cobalt oxazoline palladacycles complex, which acts as a catalyst in the rearrangement of prochiral N-aryl trifluoroacetimidates to allylic amides yielded in significantly higher enantioselectivities with the (S)-(

Application

(5-Fluoropyridin-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation with aryl and heteroaryl halides. Its fluorinated pyridine core provides enhanced metabolic stability and modulates electronic properties in pharmaceutical intermediates. The boronic acid moiety exhibits good bench stability, tolerates common functional groups, and facilitates straightforward purification—making it ideal for iterative synthesis of complex heterocyclic scaffolds in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • WO2009/61875 A2, ; Page/Page column 36-37 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -1.0995
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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