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CS-W001157 4
Total: USD 88.00

(6-Chloro-5-fluoropyridin-3-yl)boronic acid

  • CAS No. 1072946-66-7

  • Cat. No. CS-0043727
  • Purity≥97%
  • MDL No.MFCD04112500

*For research and further manufacturing use only, not for direct human use.

(6-Chloro-5-fluoropyridin-3-yl)boronic acid|CS-0043727

Structure of 1072946-66-7

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General Information

  • CAS No. 1072946-66-7
  • Cat. No. CS-0043727
  • Purity ≥97%
  • MDL No. MFCD04112500
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BClFNO₂
  • Molecular Weight 175.35
  • Synonym(s) Boronicacid, B-(6-chloro-5-fluoro-3-pyridinyl)-
  • SMILES OB(O)C1=CC(F)=C(Cl)N=C1

Description

This boronate moiety enables efficient coupling in Suzuki-Miyaura reactions, delivering functionalized heterocycles with high regioselectivity. The chloro and fluoro substituents provide orthogonal reactivity, enhancing synthetic versatility in medicinal chemistry and materials science applications.

Application

(6-Chloro-5-fluoropyridin-3-yl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its orthogonal reactivity profile—where the chloro and fluoro groups permit selective functionalization—facilitates downstream derivatization in medicinal chemistry and agrochemical synthesis. The boronic acid moiety exhibits excellent bench stability and compatibility with standard Suzuki-Miyaura coupling conditions, simplifying purification and scale-up.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.4461
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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