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3-(Propan-2-yloxy)azetidine hydrochloride

  • CAS No. 871657-49-7

  • Cat. No. CS-0051664
  • Purity≥97%
  • MDL No.MFCD06804558

*For research and further manufacturing use only, not for direct human use.

3-(Propan-2-yloxy)azetidine hydrochloride|CS-0051664

Structure of 871657-49-7

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General Information

  • CAS No. 871657-49-7
  • Cat. No. CS-0051664
  • Purity ≥97%
  • MDL No. MFCD06804558
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄ClNO
  • Molecular Weight 151.63
  • Synonym(s) 3-ISOPROPOXY-AZETIDINE HYDROCHLORIDE
  • SMILES CC(OC1CNC1)C.Cl

Description

3-(Propan-2-yloxy)azetidine hydrochloride is a bench-stable, moisture-tolerant heterocyclic building block featuring a strained azetidine ring linked to a propan-2-yloxy substituent. This combination enhances solubility and metabolic stability while enabling straightforward incorporation into medicinal chemistry campaigns. The hydrochloride salt form ensures improved handling and crystallinity for purification and formulation.

Application

3-(Propan-2-yloxy)azetidine hydrochloride serves as a stable, bench-ready building block for medicinal chemistry campaigns. The azetidine core provides a constrained, bioactive scaffold, while the isopropoxy group enhances solubility and modulates metabolic stability. It functions effectively in nucleophilic substitution and coupling reactions, enabling efficient access to diverse heterocyclic architectures. Its crystalline form facilitates purification and handling, making it well-suited for high-throughput synthesis and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.805
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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