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CS-W001157 4
Total: USD 88.00

(4-Chloro-2,6-difluorophenyl)boronic acid

  • CAS No. 925911-61-1

  • Cat. No. CS-0142973
  • Purity≥98%
  • MDL No.MFCD03095138

*For research and further manufacturing use only, not for direct human use.

(4-Chloro-2,6-difluorophenyl)boronic acid|CS-0142973

Structure of 925911-61-1

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General Information

  • CAS No. 925911-61-1
  • Cat. No. CS-0142973
  • Purity ≥98%
  • MDL No. MFCD03095138
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BClF₂O₂
  • Molecular Weight 192.36
  • Synonym(s) 4-Chloro-2,6-difluorophenylboronic acid
  • SMILES OB(C1=C(F)C=C(Cl)C=C1F)O

Description

This boronate moiety features a strategically positioned chloro and two fluorine substituents that enhance electronic modulation and metabolic stability. It integrates readily into Suzuki-Miyaura coupling reactions under standard conditions, delivering arylated products with high fidelity. The electron-deficient aromatic core enables efficient cross-coupling while maintaining bench-stable handling properties.

Application

(4-Chloro-2,6-difluorophenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its ortho-fluoro substituents enhance reactivity through stabilizing electronic effects, while the chloro group provides orthogonal functionality for downstream transformations. The compound exhibits excellent bench stability, straightforward purification, and broad functional group tolerance, making it ideal for constructing complex pharmaceutical intermediates and heterocyclic scaffolds in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.298
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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