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CS-W001157 4
Total: USD 88.00

Sodium 2'-(dicyclohexylphosphino)-2,6-diisopropylbiphenyl-4-sulfonate

  • CAS No. 870245-84-4

  • Cat. No. CS-0085102
  • Purity≥97%
  • MDL No.MFCD09265103

*For research and further manufacturing use only, not for direct human use.

Sodium 2'-(dicyclohexylphosphino)-2,6-diisopropylbiphenyl-4-sulfonate|CS-0085102

Structure of 870245-84-4

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General Information

  • CAS No. 870245-84-4
  • Cat. No. CS-0085102
  • Purity ≥97%
  • MDL No. MFCD09265103
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₀H₄₂NaO₃PS
  • Molecular Weight 536.68
  • Synonym(s) Sodium 2'-(dicyclohexylphosphino)-2,6-diisopropyl-[1,1'-biphenyl]-4-sulfonate hydrate
  • SMILES CC(C)C1=CC(S(=O)(O[Na])=O)=CC(C(C)C)=C1C2=C(P(C3CCCCC3)C4CCCCC4)C=CC=C2

Description

Sodium 2'-(dicyclohexylphosphino)-2,6-diisopropylbiphenyl-4-sulfonate is a bench-stable, moisture-tolerant ligand featuring a sterically shielded phosphine moiety paired with a sulfonate counterion. This combination enhances solubility in polar media while maintaining high electron density at the phosphorus center, enabling efficient coordination in palladium-catalyzed cross-coupling reactions under standard conditions.

Application

Sodium 2'-(dicyclohexylphosphino)-2,6-diisopropylbiphenyl-4-sulfonate serves as a highly effective ligand in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its robust steric and electronic profile enhances catalyst stability and turnover, particularly in challenging aryl-aryl and aryl-heteroaryl couplings. The sulfonate group improves solubility in aqueous/organic biphasic systems, facilitating easy purification and scalability. This ligand is widely employed in modern synthetic workflows for pharmaceutical and materials synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335-H413
Precautionary Statements : P261-P264-P271-P273-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   43.37
  • LogP   8.1618
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   8

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