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CS-W001157 4
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(5-Chloro-2-formylphenyl)boronic acid

  • CAS No. 870238-36-1

  • Cat. No. CS-W016992
  • Purity≥97%
  • MDL No.MFCD03425955

*For research and further manufacturing use only, not for direct human use.

(5-Chloro-2-formylphenyl)boronic acid|CS-W016992

Structure of 870238-36-1

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General Information

  • CAS No. 870238-36-1
  • Cat. No. CS-W016992
  • Purity ≥97%
  • MDL No. MFCD03425955
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BClO₃
  • Molecular Weight 184.38
  • Synonym(s) 5-Chloro-2-formylphenylboronic acid
  • SMILES OB(C1=CC(Cl)=CC=C1C=O)O

Description

This boronate reagent features a chlorinated aromatic core with a formyl group at the ortho position, enabling direct functionalization via Suzuki-Miyaura coupling. The electron-deficient boronic acid integrates efficiently into complex molecular architectures under standard conditions, offering high chemoselectivity and compatibility with diverse reaction partners.

Application

(5-Chloro-2-formylphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling the efficient construction of biaryl scaffolds under mild conditions. The formyl group provides orthogonal reactivity for downstream functionalization via oxime or hydrazone formation, while the boronic acid moiety offers excellent bench stability and compatibility with diverse reaction partners. Its utility is well-documented in the synthesis of pharmaceutical intermediates and functionalized heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.1677
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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