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CS-W001157 4
Total: USD 88.00

2-(1-benzylpiperidin-4-yl)ethan-1-amine

  • CAS No. 86945-25-7

  • Cat. No. CS-0199481
  • Purity≥98%
  • MDL No.MFCD02093423

*For research and further manufacturing use only, not for direct human use.

2-(1-benzylpiperidin-4-yl)ethan-1-amine|CS-0199481

Structure of 86945-25-7

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General Information

  • CAS No. 86945-25-7
  • Cat. No. CS-0199481
  • Purity ≥98%
  • MDL No. MFCD02093423
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₂N₂
  • Molecular Weight 218.34
  • Synonym(s) None
  • SMILES NCCC1CCN(CC=2C=CC=CC2)CC1

Description

This amine integrates a benzylpiperidine pharmacophore with an ethylamine tether, enabling facile conjugation in medicinal chemistry. The piperidine nitrogen and terminal amine offer dual functionalization sites, while the benzyl group enhances lipophilicity and target engagement. Designed for rapid derivatization in drug discovery workflows.

Application

2-(1-Benzylpiperidin-4-yl)ethan-1-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amine functionalization and coupling reactions. Its piperidine core offers favorable solubility and metabolic stability, while the pendant benzyl and ethylamine groups provide orthogonal reactivity for conjugation or cyclization. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, facilitating integration into multi-step syntheses of CNS-targeted pharmaceuticals and kinase inhibitors.

Synthesis

  • Route1
    • 2-(1-Benzylpiperidin-4-yl)acetonitrile|CS-W001644
      78056-67-4
    • ~91%
    • In-stock
      2-(1-benzylpiperidin-4-yl)ethan-1-amine|CS-0199481
      86945-25-7

    References

    • Journal of Medicinal Chemistry, , vol. 33, # 7 p. 1880 - 1887
  • Route2
    • null|null
      3612-20-2
    • ~%
    • In-stock
      2-(1-benzylpiperidin-4-yl)ethan-1-amine|CS-0199481
      86945-25-7

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 18 p. 4639 - 4642
  • Route3
    • 2-(1-Benzylpiperidin-4-ylidene)acetonitrile|CS-W001592
      55022-82-7
    • ~%
    • In-stock
      2-(1-benzylpiperidin-4-yl)ethan-1-amine|CS-0199481
      86945-25-7

    References

    • Journal of Medicinal Chemistry, , vol. 42, # 4 p. 730 - 741

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   2.2474
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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